Discovery of Taurocholic Acid Sodium Hydrate as a Novel Repurposing Drug for Intervertebral Disc Degeneration by Targeting MAPK3.

Ping LiZesen ChenKeyu MengYanlin ChenJiajia XuXin XiangXiuhua WuZhiping HuangRuijun LaiPeng Li Zhongming LaiXiang AoZhongyuan LiuKaifan YangXiaochun BaiZhongmin Zhang

Published in: Orthopaedic surgery (2023)

NAT would induce chondrogenesis and osteogenesis of MSCs, ameliorate the secondary osteoporosis and delay the progression of IDD in mice by targeting MAPK3.Furthermore, MAPK3, especially the phosphorylation of MAPK3, would be a potential therapeutic target for IDD treatment.

Keyphrases

signaling pathway
oxidative stress
pi k akt
mesenchymal stem cells
small molecule
type diabetes
emergency department
high throughput
cell proliferation
risk assessment
bone mineral density
high fat diet induced
protein kinase
umbilical cord
replacement therapy
wild type
smoking cessation