A prospective cohort study on association of first-trimester serum biomarkers and risk of isolated foetal congenital heart defects.

Mohammad Nasir HematianKamaran HessamiShirin TorabiMaasoumeh SalehBehnaz NouriMahboubeh Saleh

Published in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2021)

Lower PAPP-A levels and increased NT thickness were associated with an increased risk of CHDs, especially the critical type of CHDs.Clinical significanceMaternal serum PAPP-A, measured in the first trimester, is significantly lower in CHD.Foetal NT is significantly thicker in foetuses with CHD, especially those with critical CHD.Maternal serum β-hCG was only decreased among critical CHD group.

Keyphrases

gestational age
birth weight
physical activity
pregnant women
body mass index
pregnancy outcomes
weight loss