Transcriptomic analysis of α-synuclein knockdown after T3 spinal cord injury in rats.

Hong ZengBao-Fu YuNan LiuYan-Yan YangHua-Yi XingXiao-Xie LiuMou-Wang Zhou

Published in: BMC genomics (2019)

Knockdown of α-Syn after SCI enhance motor function and promote neurogenesis probably through enhancing cholinergic signaling pathways and neuroreceptor interactions. This study not only further clarifies the understanding of the mechanism of knockdown of α-Syn on SCI but also helps to guide the treatment strategy for SCI.

Keyphrases

spinal cord injury
spinal cord
neuropathic pain
signaling pathway
epithelial mesenchymal transition
oxidative stress
combination therapy
cell proliferation
induced apoptosis
neural stem cells