Cognitive impairment, the central vein sign, and paramagnetic rim lesions in RIS.

Jiwon OhSuradech SuthiphosuwanPascal Sati Martina Absinta Blake E DeweyMelanie GuenetteDaniel SelchenAditya BharathaEmily DonaldsonDaniel S Reich Anthony Feinstein

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)

CI is common in RIS and is associated with markers of perivenular demyelination and chronic inflammation in WML, such as CVS + WML and PRL. A prospective follow-up of this cohort will ascertain the importance of CI, CVS, and PRL as risk factors for conversion from RIS to MS.

Keyphrases

cognitive impairment
oxidative stress
mass spectrometry
multiple sclerosis
ms ms
drug induced