Phosphine Ligand-Free Bimetallic Ni(0)Pd(0) Nanoparticles as a Catalyst for Facile, General, Sustainable, and Highly Selective 1,4-Reductions in Aqueous Micelles.
Deborah OguluPranjal P BoraManisha BihaniSudripet SharmaTharique N AnsariAndrew J WilsonJacek B JasińskiFabrice GallouSachin HandaPublished in: ACS applied materials & interfaces (2022)
Phosphine ligand-free bimetallic nanoparticles (NPs) composed of Ni(0)Pd(0) catalyze highly selective 1,4-reductions of enones, enamides, enenitriles, and ketoamides under aqueous micellar conditions. A minimal amount of Pd (Ni/Pd = 25:1) is needed to prepare these NPs, which results in reductions without impacting N - and O -benzyl, aldehyde, nitrile, and nitro functional groups. A broad range of substrates has been studied, including a gram-scale reaction. The metal-micelle binding is supported by surface-enhanced Raman spectroscopy data on both the NPs and their individual components. Optical imaging, high-resolution transmission electron microscopy, and energy-dispersive X-ray spectroscopy analyses reveal the formation of NP-containing micelles or vesicles, NP morphology, particle size distribution, and chemical composition. X-ray photoelectron spectroscopy measurements indicate the oxidation state of each metal within these bimetallic NPs.
Keyphrases
- high resolution
- metal organic framework
- electron microscopy
- ionic liquid
- raman spectroscopy
- drug delivery
- mass spectrometry
- high speed
- tandem mass spectrometry
- cancer therapy
- drug release
- magnetic resonance imaging
- single cell
- transcription factor
- quantum dots
- gold nanoparticles
- single molecule
- nitric oxide
- electronic health record
- reduced graphene oxide
- computed tomography
- deep learning
- dna methylation
- solid phase extraction
- dna binding
- dual energy
- electron transfer