MERIT, a cellular system coordinating lysosomal repair, removal and replacement.

Jingyue JiaAurore Claude-TaupinYuexi GuSeong Won ChoiRyan PetersBhawana BissaMichal H MuddLee AllersSandeep PallikkuthKeith A LidkeMichelle SalemiBrett PhinneyMuriel MariFulvio ReggioriVojo P Deretic

Published in: Autophagy (2020)

AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; ESCRT: endosomal sorting complexes required for transport; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; TFEB: transcription factor EB; TFRC: transferrin receptor; TRIM16: tripartite motif-containing 16.

Keyphrases

protein kinase
transcription factor
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
simultaneous determination
mass spectrometry
cell proliferation
mesenchymal stem cells
liquid chromatography
nitric oxide
high resolution
bone marrow
binding protein
high resolution mass spectrometry