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Assessing the impact of unmeasured confounders for credible and reliable real-world evidence.

Xiang ZhangJames D StameyMaya B Mathur
Published in: Pharmacoepidemiology and drug safety (2020)
Various analytical methods have been proposed to address unmeasured confounding, but little research has discussed a structured approach to select appropriate methods in practice. In providing practical suggestions for choosing appropriate initial and, potentially, more specialized subsequent sensitivity analyses, we hope to facilitate the widespread reporting of such sensitivity analyses in non-interventional studies. The suggested approach also has the potential to inform pre-specification of sensitivity analyses before executing the analysis, and therefore increase the transparency and limit selective study reporting.
Keyphrases
  • adverse drug
  • healthcare
  • primary care
  • palliative care
  • risk assessment
  • quality improvement
  • human health
  • drug induced