4-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress in Chondrocytes That Is Caused by Loss of the Protein Disulfide Isomerase ERp57.

Yvonne RellmannIsabel GronauUwe Hansen Rita Dreier

Published in: Oxidative medicine and cellular longevity (2019)

ER-stress-related diseases have different sources; therefore, various targets for therapeutic treatment exist. In the future, 4-PBA may be used alone or in combination with other drugs for the treatment of ER-stress-related skeletal disorders in patients.

Keyphrases

endoplasmic reticulum stress
end stage renal disease
induced apoptosis
ejection fraction
newly diagnosed
chronic kidney disease
small molecule
binding protein
patient reported outcomes
replacement therapy
smoking cessation