Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis.

Roxana WasnickMartina KorfeiKatarzyna PiskulakIngrid HennekeJochen WilhelmPoornima MahavadiRuth Charlotte DartschDaniel von der BeckMiriam KochIrina ShalashovaAstrid WeissOleksiy KlymenkoIngolf AskevoldLudger FinkHeiko WittHolger HacksteinElie El AghaSaverio BellusciWalter KlepetkoMelanie Königshoff Oliver EickelbergRalph Theo SchermulyThomas BraunWerner SeegerClemens RuppertAndreas Guenther

Published in: American journal of respiratory and critical care medicine (2022)

Notch1 is a central regulator of AEC2 fate in IPF. It induces alveolar epithelial proliferation, loss of Napsin A and of surfactant proprotein processing and it contributes to fibroproliferation.

Keyphrases

pulmonary fibrosis
cell proliferation
idiopathic pulmonary fibrosis
signaling pathway
transcription factor