Brahma-Related Gene 1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion.

Yongjie ZhouYuwei ChenXiaoyun ZhangQing XuZhenru WuXiaoyue CaoMingyang ShaoYuke ShuTao LvChangli LuMingjun XieTianfu WenJiayin YangYu-Jun ShiHong Bu

Published in: Hepatology (Baltimore, Md.) (2021)

We have demonstrated the function of Brg1 in promoting HPC expansion, liver cirrhosis, and, ultimately, iCCA development in chronically injured livers, which is largely dependent on Wnt/β-catenin signaling. Our data suggest that therapies targeting Brg1-expressing HPCs are promising for the treatment of liver cirrhosis and iCCA.

Keyphrases

liver fibrosis
electronic health record
cancer therapy
mouse model
drug delivery
transcription factor
data analysis
deep learning