Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma.

David A SchoenfeldRoyce ZhouSakellarios ZairisWilliam SuNicole SteinbachDeepti MathurAnkita Bansal Alexis L ZachemBertilia TavarezDan HassonEmily BernsteinRaul RabadanRamon E Parsons

Published in: Molecular cancer research : MCR (2022)

This study implicates the SWI/SNF subunit and tumor-suppressor PBRM1 in the regulation of promoter histone modifications and retinoic acid biosynthesis and signaling pathways in ccRCC and functionally validates one such target gene, the aldehyde dehydrogenase ALDH1A1.

Keyphrases

dna methylation
renal cell carcinoma
genome wide
gene expression
signaling pathway
transcription factor
copy number