Management of pulmonary Scedosporium apiospermum infection by thoracoscopic surgery in an immunocompetent woman.
Wei LiuRuizhi FengHongli JiangPublished in: The Journal of international medical research (2021)
The Scedosporium apiospermum complex is a group of emerging opportunistic fungal pathogens that affect both immunocompromised and immunocompetent individuals, most commonly via lung infection. Although they are resistant to many antifungal agents, this group of pathogens has a favorable susceptibility profile to azoles, especially voriconazole. Here, we describe the management of S. apiospermum infection in an otherwise healthy 44-year-old woman. She had exhibited intermittent hemoptysis for 2 years before admission to our hospital. Computed tomography revealed a thin-walled and well-circumscribed cavitary lesion in the left upper lobe; the lesion was filled with consolidative opacities. Fungal culture of bronchoalveolar lavage fluid specimens revealed grayish-white mold; lactophenol cotton blue staining revealed acute angle branched septate hyaline cylindrical hyphae, characteristic of S. apiospermum. Despite voriconazole 200 mg twice daily for 8 weeks, the patient showed no improvement; thus, her left upper lobe was removed via thoracoscopic surgery. Her symptoms immediately improved and chest radiography after surgical resection showed no evidence of radiological progression or reoccurrence. This report demonstrates that S. apiospermum lung infection may not respond well to voriconazole alone in immunocompetent hosts; thus, surgery could be curative for these patients.
Keyphrases
- minimally invasive
- coronary artery bypass
- computed tomography
- case report
- single cell
- emergency department
- end stage renal disease
- prognostic factors
- healthcare
- physical activity
- gram negative
- high resolution
- pulmonary hypertension
- depressive symptoms
- liver failure
- ejection fraction
- chronic kidney disease
- intensive care unit
- magnetic resonance
- candida albicans
- peritoneal dialysis
- acute coronary syndrome
- multidrug resistant
- contrast enhanced
- sleep quality
- extracorporeal membrane oxygenation
- ultrasound guided
- fine needle aspiration