Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.

Yu-Chen Wang Yen Chin KoayCalvin PanZhiqiang Zhou Wai Hong Wilson Tang Jennifer D Wilcox Xinmin S LiAlexia ZagourasFrancine Z Marques Hooman Allayee Federico E Rey David M Kaye John F O'Sullivan Stanley L HazenYang CaoAldons J Lusis

Published in: Circulation research (2024)

Our findings reveal that IPA protects against diastolic dysfunction in HFpEF by enhancing the nicotinamide adenine dinucleotide salvage pathway, suggesting the possibility of therapeutic management by either altering the gut microbiome composition or supplementing the diet with IPA.

Keyphrases

left ventricular
blood pressure
physical activity
weight loss
genome wide
oxidative stress
single cell
ejection fraction
gene expression