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Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6.

Shuo QieJ Alan Diehl
Published in: Molecular & cellular oncology (2019)
Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine-addiction in esophageal squamous cell carcinoma. This metabolism feature makes these tumors susceptible to combined treatment with glutaminase (GLS) inhibitor and metformin even when resisting to CDK4/6 inhibitors.
Keyphrases
  • cell cycle
  • cell proliferation
  • binding protein
  • machine learning
  • transcription factor
  • protein kinase
  • cell death
  • signaling pathway
  • neural network