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Endothelial life discontinues without Erk.

Yihai Cao
Published in: The Journal of experimental medicine (2019)
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In this issue of JEM, Ricard et al. (https://doi.org/10.1084/jem.20182151) discover essential roles of ERK1/2 in maintaining endothelial homeostasis and its deletion-related serious defects in multiple tissues and organs.
Keyphrases
  • endothelial cells
  • signaling pathway
  • cell proliferation
  • pi k akt
  • gene expression