Genetic Architecture of Stroke of Undetermined Source: Overlap with Known Stroke Etiologies and Associations with Modifiable Risk Factors.

Marios K Georgakis Livia Parodi Simon FrerichErnst MayerhoferGeorgios K TsivgoulisJames P PirruccelloAgnieszka SlowikTatjana RundekRainer MalikMartin DichgansJonathan RosandChristopher D Andersonnull null

Published in: Annals of neurology (2022)

Stroke of undetermined source shares genetic and vascular risk factors with other stroke subtypes, especially LAAS, thus highlighting the diagnostic limitations of current subtyping approaches. The potentially causal associations with carotid atherosclerosis and atherosclerotic risk factors might have implications for prevention strategies targeting these mechanisms. ANN NEUROL 2022;91:640-651.

Keyphrases

risk factors
atrial fibrillation
cardiovascular disease
copy number
cerebral ischemia
gene expression
dna methylation
neural network