Low-dose versus standard-dose alteplase in acute ischemic stroke in Asian stroke registries: an individual patient data pooling study.

Xia WangJingwei LiTom James MoullaaliKeon-Joo LeeBeom Joon KimHee-Joon BaeAnxin WangYilong WangDavid Z WangYongjun WangMasaya KumamotoKazunori ToyodaMasatoshi KogaShoichiro SatoSohei YoshimuraYi SuiBing XuYing XiaoTsong-Hai LeeChia-Wei LiouJiann-Der LeeTsung-I PengYen-Chu HuangPrakash R PaliwalManasi SharmaCyrus EscabillasJose C NavarroMu-Chien SunYi DongQiang DongCraig S Anderson Vijay Kumar Sharma

Published in: International journal of stroke : official journal of the International Stroke Society (2019)

The present analyses of real-world Asian acute stroke registry data suggest that low-dose intravenous alteplase has overall comparable efficacy for functional recovery and greater potential safety in terms of reduced mortality, to standard-dose alteplase for the treatment of acute ischemic stroke.

Keyphrases

acute ischemic stroke
low dose
high dose
electronic health record
big data
atrial fibrillation
case report
risk factors
type diabetes
brain injury
risk assessment