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Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate.

Mysore Bhyrappa HarishaPandi DhanalakshmiRajendran SureshRaju Ranjith KumarShanmugam Muthusubramanian
Published in: Beilstein journal of organic chemistry (2020)
The reactivity of α-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2H-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5-trisubstituted oxazoles in good yields. Incidentally, 2-aminothiazoles are the products when ferric nitrate is employed instead of persulfate in the above reaction.
Keyphrases
  • molecular docking
  • drinking water
  • molecularly imprinted
  • newly diagnosed
  • molecular dynamics simulations
  • liquid chromatography
  • solid phase extraction
  • aqueous solution