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Delivery of Cargo with a Bioelectronic Trigger.

Zahra HemmatianElmira JalilianSangeun LeeXenofon StrakosasAli KhademhosseiniAdah AlmutairiSu Ryon ShinMarco Rolandi
Published in: ACS applied materials & interfaces (2018)
Biological systems exchange information often with chemical signals. Here, we demonstrate the chemical delivery of a fluorescent label using a bioelectronic trigger. Acid-sensitive microparticles release fluorescin diacetate upon low pH induced by a bioelectronic device. Cardiac fibroblast cells (CFs) uptake fluorescin diacetate, which transforms into fluorescein and emits a fluorescent signal. This proof-of-concept bioelectronic triggered delivery may be used in the future for real-time programming and control of cells and cell systems.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • single cell
  • stem cells
  • oxidative stress
  • signaling pathway
  • current status
  • cell proliferation
  • pi k akt