The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration.

Dezhen TuYun GaoRu YangTian GuanJau-Shyong HongHui-Ming Gao

Published in: Journal of neuroinflammation (2019)

Our findings indicated that G6PD-mediated PPP dysfunction and neuroinflammation exacerbated each other mediating chronic dopaminergic neurodegeneration and locomotor impairment. Insight into metabolic-inflammatory interface suggests that G6PD and NOX2 are potential therapeutic targets for PD.

Keyphrases

traumatic brain injury
lipopolysaccharide induced
oxidative stress
lps induced
spinal cord injury
cognitive impairment
cerebral ischemia
blood brain barrier