Cocaine's effects on the reactivity of the medial prefrontal cortex to ventral tegmental area stimulation: optical imaging study in mice.

Kicheon Park Kevin M Clare Nora D Volkow Yingtian Pan Congwu Du

Published in: Addiction (Abingdon, England) (2022)

Acute cocaine impairs reactivity of medial prefrontal cortex (mPFC) to ventral tegmental area stimulation, decreasing its sensitivity to 'tonic-like' stimulation and lengthening the recovery time to return to baseline while shortening it for phasic stimulation. These changes in mPFC might contribute to cocaine binging during intoxication.

Keyphrases

prefrontal cortex
high resolution
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deep brain stimulation