Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea irritable bowel syndrome.

Michele LinsalataLaura ProsperoGiuseppe RiezzoAntonella OrlandoBenedetta D'AttomaAntonia IgnazziFrancesco Russo

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)

These data support the multifactorial IBS pathogenesis in which organic and psychological factors interact. An active role by VD, 5-HT, and BDNF in affecting the clinical and biochemical profiles in IBS-D(S+) patients may be conceivable. Therefore, the routine VD estimation and the assay of circulating levels of 5-HT and BDNF could be considered a new approach for managing these patients.

Keyphrases

irritable bowel syndrome
end stage renal disease
newly diagnosed
peritoneal dialysis
machine learning
physical activity
clinical practice
patient reported