Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.

Rik SchoemakerJanet R WadeArmel Stockis

Published in: European journal of clinical pharmacology (2017)

A paediatric dose adaptation of 2.0 mg/kg twice daily with a maximum of 100 mg twice daily for body weight >50 kg is predicted to ensure steady-state plasma concentrations in the same range as in adult patients receiving 100 mg twice daily (highest recommended dose). Data suggest no need to change brivaracetam dosing when used concomitantly with carbamazepine, phenobarbital or valproate.

Keyphrases

body weight
physical activity
emergency department
intensive care unit
young adults
electronic health record
big data
machine learning
artificial intelligence
childhood cancer