Plasminogen deficiency does not prevent sodium retention in a genetic mouse model of experimental nephrotic syndrome.

Mengyun XiaoBernhard N BohnertHande AypekOliver KretzFlorian GrahammerUte AukschunMatthias WörnAndrea JanessaDaniel EssigkeChristoph DanielKerstin AmannTobias B HuberEdward F PlowAndreas L BirkenfeldFerruh Artunc

Published in: Acta physiologica (Oxford, England) (2020)

This study shows that mice lacking urinary plasminogen are not protected from ENaC-mediated sodium retention in experimental NS. This points to an essential role of other urinary serine proteases in the absence of plasminogen.

Keyphrases

mouse model
genome wide
high fat diet induced
gene expression
adipose tissue