Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction.
William P AdamsTristan B RaischYajun ZhaoRafael V DavalosSarah BarrettD Ryan KingChandra B BainKatrina Colucci-ChangGrace A BlairAlexandra L HanlonAlicia J LozanoRengasayee VeeraraghavanXiaoping WanIsabelle DeschenesJames W SmythGregory S HoekerRobert G GourdieSteven PoelzingPublished in: Circulation research (2023)
Cardiac conduction does not correlate with extracellular resistance but is biphasically related to perinexal separation, providing evidence that the relationship between CV and extracellular volume is determined by ephaptic mechanisms under conditions of normal gap junctional coupling.