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Proton Therapy in the Management of Hepatocellular Carcinoma.

Jana M KobeissiLara HilalCharles B Simone IiHaibo LinChristopher H CraneCarla Hajj
Published in: Cancers (2022)
Proton radiation therapy plays a central role in the treatment of hepatocellular carcinoma (HCC). Because of the near-zero exit dose and improved sparing of normal liver parenchyma, protons are being used even in challenging scenarios, including larger or multifocal liver tumors, and those associated with vascular tumor thrombus. There is a mounting level of evidence that suggests that protons are superior to photons in terms of survival and toxicity outcomes, specifically the progression to liver failure. A randomized controlled trial comparing protons to photons is currently underway to verify this hypothesis.
Keyphrases
  • liver failure
  • radiation therapy
  • hepatitis b virus
  • climate change
  • oxidative stress
  • type diabetes
  • robot assisted
  • radiation induced
  • adipose tissue
  • free survival
  • replacement therapy