Single-cell sequencing analysis reveals development and differentiation trajectory of Schwann cells manipulated by M. leprae.

Shanshan MaZihao MiZhenzhen WangLele SunTingting LiuPeidian ShiChuan WangXiaotong XueWenjie ChenZhe WangYueqian YuYuan ZhangFangfang BaoNa WangHonglei WangQianqian XiaHong LiuYonghu SunFuren Zhang

Published in: PLoS neglected tropical diseases (2023)

Our results present a systematic time-course analysis of SC heterogeneity after infection by M. leprae at single-cell resolution, provide valuable information to understand the critical biological processes underlying reprogramming and lipid metabolism during M. leprae infection of SCs, and increase understanding of the disease-causing mechanisms at play in leprosy patients as well as revealing potential new therapeutic strategies.

Keyphrases

single cell
rna seq
end stage renal disease
high throughput
ejection fraction
newly diagnosed
induced apoptosis
chronic kidney disease
prognostic factors
healthcare
cell proliferation
single molecule
oxidative stress
health information
climate change
peripheral nerve
endoplasmic reticulum stress