CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Bruton's Tyrosine Kinase Inhibition.

Alan CooperSravya TumuluruKyle KissickGirish VenkataramanJoo Y Song Andrew LytleGerben DunsJovian Yu Nikita Kotlov Alexander V BagaevBrendan HodkinsonSrimathi SrinivasanSonali M SmithDavid W Scott Christian Steidl James K Godfrey Justin Kline

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

CD5sig is a useful biomarker to identify DLBCLs vulnerable to BTKi-based therapies and complements current biomarker approaches by identifying DLBCLs with genetic and nongenetic bases for BTKi sensitivity.

Keyphrases

tyrosine kinase
genome wide
epidermal growth factor receptor
copy number
dna methylation
nk cells
low grade
gene expression
genome wide identification
high grade