Frequent Premature Atrial Contractions Lead to Adverse Atrial Remodeling and Atrial Fibrillation in a Swine Model.
Satoshi HiguchiAleksandr VoskoboinikSung Il ImAdam LeeJeffrey E OlginAyla ArbilJunaid AfzalGregory M MarcusCarol StillsonDwight BibbyTheodore AbrahamEmily WilsonEdward P GerstenfeldPublished in: Circulation (2023)
In this swine model, frequent PACs resulted in adverse atrial structural remodeling with a heightened propensity to AF. PACs originating from the lateral LA produced greater atrial remodeling and longer induced AF duration than the septal-origin PACs. These data provide evidence that frequent PACs can cause adverse atrial remodeling as well as AF, and that the location of ectopic PACs may be clinically meaningful.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- electronic health record
- adverse drug
- left ventricular
- emergency department
- diabetic rats
- venous thromboembolism
- big data
- oxidative stress
- hypertrophic cardiomyopathy