α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function.

Ziping YeYunjuan ZhuNana TangXiaojing ZhaoJingyue JiangJingjing MaHong-Jie Zhang

Published in: Molecular medicine (Cambridge, Mass.) (2022)

The α7nAChR agonist GTS-21 attenuated DSS-induced colitis through increasing expressions of TJ proteins in colon tissues and improved intestinal barrier function, which might be due to modulating NF-қB activation in intestinal epithelial cells.

Keyphrases

signaling pathway
gene expression
oxidative stress
diabetic rats
stress induced