Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil.

M K Chaitanya Mannava Manish K Bommaka Rambabu Dandela Anand Solomon Kamalakaran Ashwini K Nangia

Published in: Chemical communications (Cambridge, England) (2022)

Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

Keyphrases

endothelial cells
ionic liquid
adverse drug
drug induced
atomic force microscopy
mass spectrometry
biofilm formation