M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3.

Yuan XiongLang ChenChenchen YanWu ZhouTao YuYun SunFaqi CaoHang XueYiqiang HuDong ChenBobin MiGuohui Liu

Published in: Journal of nanobiotechnology (2020)

Our study demonstrates that miR-5106 is highly enriched in M2D-Exos, and that it can be transferred to BMSCs wherein it targets SIK2 and SIK3 genes to promote osteoblast differentiation.

Keyphrases

mesenchymal stem cells
cell proliferation
long non coding rna
genome wide
bone mineral density
bone regeneration
long noncoding rna
umbilical cord
tyrosine kinase
dna methylation
cell therapy
protein kinase
postmenopausal women
vascular smooth muscle cells
gene expression
genome wide identification