Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders.
Yan LiuJohn Man Tak ChuYou RanYan ZhangRaymond Chuen Chung ChangGordon Tin Chun WongPublished in: Journal of neuroinflammation (2022)
Resistance exercise reduced risk factors for perioperative neurocognitive disorders such as increased body weight, elevated inflammatory markers, and pre-existing cognitive impairment. Accordantly, preoperative resistance exercise improved surgery-induced adverse effects including cognitive impairment, synaptic deficit and neuroinflammation, possibly by facilitate mitochondrial health through the PGC1-a/BDNF pathway.
Keyphrases
- cognitive impairment
- body weight
- high intensity
- patients undergoing
- healthcare
- public health
- physical activity
- oxidative stress
- resistance training
- traumatic brain injury
- bipolar disorder
- minimally invasive
- lipopolysaccharide induced
- health information
- skeletal muscle
- lps induced
- metabolic syndrome
- diabetic rats
- high glucose
- risk assessment
- type diabetes
- inflammatory response
- social media
- insulin resistance
- high fat diet induced
- human health
- body composition
- percutaneous coronary intervention
- adipose tissue
- prefrontal cortex