Cardiac radiotherapy transiently alters left ventricular electrical properties and induces cardiomyocyte-specific ventricular substrate changes in heart failure.

Felix Mehrhof Judith Huettemeister Radu Tanacli Matthias Bock Markus Bögner Felix Schoenrath Volkmar Falk Daniel Zips Gerhard Hindricks Jin-Hong Gerds-Li Felix Hohendanner

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)

Our study supports the notion of transiently altered cardiac conduction potentially related to structural and functional cellular changes as an underlying mechanism of cRA in patients with ventricular tachycardia.

Keyphrases

left ventricular
heart failure
cardiac resynchronization therapy
hypertrophic cardiomyopathy
acute myocardial infarction
left atrial
aortic stenosis
mitral valve
early stage
radiation therapy
locally advanced
angiotensin ii
atrial fibrillation
acute heart failure
acute coronary syndrome
structural basis