Metformin use is not associated with colorectal cancer incidence in type-2 diabetes patients: evidence from methods that avoid immortal time bias.
Hyun-Soo ZhangYeunsoo YangSunmi LeeSo Hee ParkChung Mo NamSun Ha JeePublished in: International journal of colorectal disease (2022)
The association between metformin use and subsequent CRC incidence was statistically nonsignificant after accounting for time-related biases such as ITB. Previous studies that avoided these biases and meta-analyses of RCTs on metformin and cancer incidence were in agreement with our results. A definitive, large-scale RCT is needed to clarify this topic, and future observational studies should be explicit in avoiding ITB and other time-related biases.
Keyphrases
- type diabetes
- risk factors
- meta analyses
- end stage renal disease
- newly diagnosed
- systematic review
- ejection fraction
- chronic kidney disease
- cardiovascular disease
- papillary thyroid
- prognostic factors
- adipose tissue
- squamous cell carcinoma
- glycemic control
- metabolic syndrome
- patient reported outcomes
- current status
- young adults
- patient reported