Royal jelly arranges apoptotic and oxidative stress pathways and reduces damage to liver tissues of rats by down-regulation of Bcl-2, GSK3 and NF-κB and up-regulation of Caspase and Nrf-2 protein signaling pathways.
Abdullah AslanOzlem GokSeda BeyazGozde ParlakMuhammed Ismail CanRamazan GundogduSerpil BaspinarIbrahim Hanifi OzercanAkif Evren ParlakPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2022)
Our findings suggest RJ to be used as a hepatoprotective agent in the clinic to modulate the toxic effects of fluoride and other chemicals in the future.
Keyphrases
- oxidative stress
- signaling pathway
- induced apoptosis
- pi k akt
- cell death
- diabetic rats
- dna damage
- ischemia reperfusion injury
- gene expression
- primary care
- drinking water
- epithelial mesenchymal transition
- current status
- umbilical cord
- lps induced
- mesenchymal stem cells
- inflammatory response
- anti inflammatory
- endoplasmic reticulum stress
- amino acid
- small molecule
- heat shock protein