Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.

Arjan MofersPaola PeregoKarthik SelvarajuLaura GattiJoachim GullboStig LinderPadraig D'Arcy

Published in: PloS one (2019)

The proteasome DUB inhibitors b-AP15/VLX1570 are cell cycle-active. The slow and incomplete development of resistance towards these compounds is an attractive feature in view of future clinical use.

Keyphrases

cell cycle
small molecule
cell proliferation
transcription factor
machine learning
current status
protein protein
deep learning
neural network