TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads.
Hui-Zhi LowGerrit AhrenstorfClaudia PommerenkeNadine HabermannKlaus SchughartDavid OrdóñezRenata StripeckeEsther WilkTorsten WittePublished in: Retrovirology (2016)
Our experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8. However, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. We believe that more work has to be done to study the role of LILRA3 in infectious diseases and that there is a potential for exploring the use of LILRA3 in the treatment of virus infections.
Keyphrases
- infectious diseases
- antiretroviral therapy
- toll like receptor
- inflammatory response
- immune response
- endothelial cells
- hiv infected
- human immunodeficiency virus
- hiv positive
- hepatitis c virus
- peripheral blood
- hiv testing
- nuclear factor
- disease virus
- induced pluripotent stem cells
- men who have sex with men
- climate change
- nk cells