Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.

Yu SunKate StensonMaradumane L MohanManveen K GuptaNicholas WannerKewal AsosinghSerpil ErzurumSathyamangla Venkata Naga Prasad

Published in: Circulation research (2023)

Agonist-independent activation of PI3Kγ underlies hypoxia sensing as its ablation leads to reduction in β1- and β2AR phosphorylation and amelioration of cardiac dysfunction.

Keyphrases

endothelial cells
left ventricular
oxidative stress
protein kinase
binding protein
atrial fibrillation
catheter ablation