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Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.

Yu SunKate StensonMaradumane L MohanManveen K GuptaNicholas WannerKewal AsosinghSerpil ErzurumSathyamangla Venkata Naga Prasad
Published in: Circulation research (2023)
Agonist-independent activation of PI3Kγ underlies hypoxia sensing as its ablation leads to reduction in β1- and β2AR phosphorylation and amelioration of cardiac dysfunction.
Keyphrases
  • endothelial cells
  • left ventricular
  • oxidative stress
  • protein kinase
  • binding protein
  • atrial fibrillation
  • catheter ablation