PRMT5-mediated H4R3sme2 Confers Cell Differentiation in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia.
Mei MeiRuidong ZhangZhong-Wei ZhouZhengzhou YingJincheng WangHuyong ZhengShilai BaoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
We demonstrate that enhanced PRMT5 promotes BCP-ALL leukemogenesis partially by the dysregulation of B-cell lineage differentiation. H4R3sme2 and PRMT5 may serve as potential sensitive biomarkers of pediatric BCP-ALL. Suppression of the activation of PRMT5 may offer a promising therapeutic strategy against pediatric BCP-ALL.