Production of 11-oxygenated androgens by testicular adrenal rest tumors.
Mariska A M SchröderAdina F TurcuPatrick O'DayAntonius E van HerwaardenPaul N SpanRichard J AuchusFred C G J SweepHedi L Claahsen-van der GrintenPublished in: The Journal of clinical endocrinology and metabolism (2021)
In patients with 21OHD, TART produce 11oxC19 steroids, but in different proportions than the adrenals. The very high ratio of 11OHT in spermatic- versus peripheral vein blood suggests the 11-hydroxylation of testosterone by TART, and the in vitro results indicate that this metabolism is ACTH-sensitive.