Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized-controlled ELAN Trial.
Roman RohnerMarkus KneihslMartina Béatrice GoeldlinArsany HakimMattia BrancaStefanie AbendWaldo Valenzuela PinillaSabine FenzlBeata Rezny-KasprzakStrbian DanielSven TrelleMaurizio PaciaroniGötz ThomallaPatrik MichelKrassen NedeltchevThomas GattringerElse Chartlotte SandsetLeo H BonatiDiana Aguiar de SousaPadmavathyamma Narayanapillai SylajaGeorge NtaiosMasatoshi KogaZuzana GdovinováRobin LemmensNatan M BornsteinPeter J KellyMira KatanThomas HorvathJesse DawsonUrs Fischernull nullPublished in: Circulation (2024)
We found no evidence of major treatment effect heterogeneity or safety concerns with early versus late DOAC initiation in people with and without HT. However, early DOAC initiation may worsen functional outcomes in people with PH.