Identification and Validation of T-Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data.

Yaowu ZhuLi TanDanju LuoXiong Wang

Published in: Diagnostics (Basel, Switzerland) (2024)

We established and validated a T-cell exhaustion-related prognostic signature for patients with PACA. Moreover, our study suggests that SPOCK2 is a novel marker of exhausted CD8+ T cells.

Keyphrases

single cell
immune response
rna seq
high throughput
electronic health record
deep learning
data analysis
artificial intelligence
drug induced