3-Methyladenine but not antioxidants to overcome BACH2-mediated bortezomib resistance in mantle cell lymphoma.

Min FengJia WangMing SunGuilan LiBingXiang LiRuidong Zhang

Published in: Cancer cell international (2021)

Our results dissected the interconnected molecular network in resistant MCL cells in which 3-MA represents an effective therapeutic strategy to overcome BTZ resistance. Notably, BACH1 and BACH2, albeit from the same family, are likely to play opposite roles in pathogenesis and progression of MCL.

Keyphrases

induced apoptosis
cell cycle arrest
multiple myeloma
newly diagnosed
single molecule
cell proliferation
network analysis