Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway.

Qin ZhangMei ZhengCristian E BetancourtLifeng LiuAlbert SitikovNikola SladojevicQiong ZhaoArne P NeyrinckJames K LiaoRongxue Wu

Published in: Oxidative medicine and cellular longevity (2021)

MMP3 increases BBB permeability following the administration of isoflurane by upregulating the ERK signaling pathway, which subsequently reduces TJ and VE-cadherin proteins in BMVECs.

Keyphrases

blood brain barrier
signaling pathway
pi k akt
cell migration
induced apoptosis
epithelial mesenchymal transition
cerebral ischemia
endothelial cells
cell proliferation
brain injury
cell adhesion