Rifampicin reduces plasma concentration of linezolid in patients with infective endocarditis.
Magnus BockJohan G C van HasseltFranziska SchwartzHengzhuang WangNiels HøibyKurt FuurstedNikolaj IhlemannSabine GillUlrik ChristiansenNiels Eske BruunHanne ElmingJonas A PovlsenLars Valeur KøberDan E HøfstenEmil L FosbølMia M Pries-HejeJens Jørgen ChristensenFlemming Schønning RosenvingeChristian Torp-PedersenJannik Helweg-LarsenNiels TønderKasper Karmark IversenHenning BundgaardClaus MoserPublished in: The Journal of antimicrobial chemotherapy (2023)
A substantial interaction between linezolid and rifampicin was detected in patients with infective endocarditis, and the interaction was stronger than previously reported. Model-based simulations showed that increasing the linezolid dose might compensate without increasing the risk of adverse effects to the same degree.