Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity.
Iuliia EfimovaElena CatanzaroLouis Van der MeerenVictoria D TurubanovaHamida HammadTatiana A MishchenkoMaria V VedunovaCarmela FimognariClaus BachertFrauke CoppietersSteve LefeverAndre G SkirtachOlga KryskoDmitri V KryskoPublished in: Journal for immunotherapy of cancer (2021)
These results pave the way for the development of new therapeutic strategies for cancers based on induction of ferroptosis, and thus broadens the current concept of immunogenic cell death and opens the door for the development of new strategies in cancer immunotherapy.