The influence of high-density lipoprotein (HDL) and HDL subfractions on insulin secretion and cholesterol efflux in pancreatic derived β-cells.
A Ochoa-GuzmánD Guillén-QuinteroL Muñoz-HernándezA GarcíaE Díaz-DíazO Pérez-MéndezR Rodríguez-GuillénI B Mitre-AguilarA Zentella-DehesaC A Aguilar-SalinasMaría Teresa Tusié-LunaPublished in: Journal of endocrinological investigation (2021)
HDL can trigger insulin secretion under low, normal, and high glucose conditions. We found that all HDL subfractions exhibit very similar capacity to increase insulin secretion and cholesterol efflux. This is the first report demonstrating that HDL subfractions act both as insulin secretagogues (under low glucose) and insulin secretion enhancers (under high glucose) in the MIN-6 cell line.