Rare single-nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome.

Seyed Mohsen MirabdolhosseiniMohammad Yaghoob TaleghaniLeili RejaliHossein SadeghiNayeralsadat FatemiMehdi TavallaeiAmin Famil MeyariNarges SaeidiPardis Ketabi MoghadamAmir SadeghiHamid Asadzadeh AghdaeiMohammad Reza ZaliEhsan Nazemalhosseini Mojarad

Published in: Cancer reports (Hoboken, N.J.) (2023)

Overall, our results suggest that analysis of MLH1 and MSH2 genes alone is insufficient in the Iranian population, and more comprehensive tests are recommended for detecting LS.

Keyphrases

genome wide
bioinformatics analysis
genome wide identification
copy number
genome wide analysis
case report
gene expression