GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: a comparison across modes of programmed cell death and mitochondrial involvement.

Chanon PiamsiriChayodom ManeechoteKewarin JinawongBusarin ArunsakTitikorn ChunchaiWichwara NawaraSiriporn C ChattipakornSiriporn C Chattipakorn

Published in: Journal of translational medicine (2023)

In this study, we provide the first insights into the mechanism of PCDs by pyroptosis, which is leveraged as the most dominant mode of cell death after MI.

Keyphrases

left ventricular
cell death
heart failure
oxidative stress
nlrp inflammasome
acute myocardial infarction
hypertrophic cardiomyopathy
cardiac resynchronization therapy
aortic stenosis
acute coronary syndrome
coronary artery disease